PEARSON LAB

Easy to read bibliography at NCBI here

Research Publications from the Pearson Lab

2021

TOR is required for injury-induced activation of slow-cycling neoblasts in planarians

Alyssa M. Molinaro, Nicole Lindsay-Mosher, and Bret J. Pearson
EMBO Reports coming soon!

2020

One Stem Cell to Rule Them All?

Mallory Wiggans and Bret J. Pearson
FEBS Journal https://doi.org/10.1111/febs.15598

An optimized QF-binary expression system for use in Zebrafish

Jason Burgess, Jeffrey T. Burrows, Roshan Sadhak, Sharon Chiang, Alex Weiss, Cassandra D’Amata, Alyssa M. Molinaro, Shujun Zhu, Michael Long, Chun Hu, Ramil Noche, James Dowling, Henry M. Krause, Bret J. Pearson
Developmental Biology 465(2):144-56. https://doi.org/10.1016/j.ydbio.2020.07.007

A Novel Taxon of Monosegmented Double-Stranded RNA Viruses Endemic to Triclad Flatworms

Jeffrey Burrows, Delphine Depierreux, Max L. Nibert, and Bret J. Pearson
J. Virology 94:e00623-20 https://doi.org/10.1101/551184

Planarian EGF-repeat containing genes megf6 and hemicentin are required to restrict the stem cell compartment

Nicole Lindsay-Mosher, Andy Chan, and Bret J. Pearson
PLoS Genetics 16(2):e1008613

2018

Smed-myb-1 specifies early temporal identity during planarian epidermal differentiation

Zhu SJ and Pearson BJ.
Cell Reports 25:38

Comparative transcriptomic analyses and single-cell RNA sequencing of the freshwater planarian Schmidtea mediterranea identify major cell types and pathway conservation.

Swapna LS, Molinaro AM, Lindsay-Mosher N, Pearson BJ, Parkinson J .
Genomoe Biology. 2018; Aug 24;19(1):124.

The true colours of the flatworm: Mechanisms of pigment biosynthesis and pigment cell lineage development in planarians.

Lindsay-Mosher, N and Pearson BJ.
Seminars in Cell and Developmental Biology. 2018; S1084-9521(17)30194-5.

Myths vs. FACS: what do we know about planarian stem cell lineages?

Molinaro AM and Pearson BJ.
Int J Dev Bio. 2018; 62(6-7-8):527-535.

The planarian TCF/LEF factor Smed-tcf1 is required for the regeneration of dorsal-lateral neuronal subtypes.

Brown DDR, Molinaro AM, Pearson BJ.
Developmental Biology. 2018; 433(2):374-383.

2017

FOX and ETS family transcription factors regulate the pigment cell lineage in planarians.

He X, Lindsay-Mosher N, Li Y, Molinaro AM, Pellettieri J, Pearson BJ.
Development. 2017; 144(24):4540-4551.

Yorkie is required to restrict the injury responses in planarians.

Lin AYT, Pearson BJ.
PLoS Genetics. 2017; 13(7):e1006874.

A Brain Unfixed: Unlimited Neurogenesis and Regeneration of the Adult Planarian Nervous System.

Brown DDR, Pearson BJ.
Frontiers in Neuroscience. 2017; 11:289.

Nervous system development and regeneration in freshwater planarians.

Ross KG, Currie KW, Pearson BJ, Zayas RM.
Wiley interdisciplinary reviews. Developmental Biology. 2017; 6(3).

2016

Neuronal sources of hedgehog modulate neurogenesis in the adult planarian brain.

Currie KW, Molinaro AM, Pearson BJ.
eLife. 2016; 5.

(Neo)blast from the past: new insights into planarian stem cell lineages.

Zhu SJ, Pearson BJ.
Current Opinion in Genetics & Development. 2016; 40:74-80.

Light-induced depigmentation in planarians models the pathophysiology of acute porphyrias.

Stubenhaus BM, Dustin JP, Neverett ER, Beaudry MS, Nadeau LE, Burk-McCoy E, He X, Pearson BJ, Pellettieri J.
eLife. 2016; 5.

In silico lineage tracing through single cell transcriptomics identifies a neural stem cell population in planarians.

Molinaro AM, Pearson BJ.
Genome Biology. 2016; 17:87.

HOX gene complement and expression in the planarian Schmidtea mediterranea.

Currie KW, Brown DD, Zhu S, Xu C, Voisin V, Bader GD, Pearson BJ.
EvoDevo. 2016; 7:7.

2015

A mex3 homolog is required for differentiation during planarian stem cell lineage development.

Zhu SJ, Hallows SE, Currie KW, Xu C, Pearson BJ.
eLife. 2015 Jun 26;4.

An in vivo requirement for the mediator subunit med14 in the maintenance of stem cell populations.

Burrows JT, Pearson BJ, Scott IC.
Stem Cell Reports. 2015 Apr 14;4(4):670-84.

2014

Planarian yorkie/YAP functions to integrate adult stem cell proliferation, organ homeostasis and maintenance of axial patterning.

Lin AY, Pearson BJ.
Development. 2014 Mar;141(6):1197-208.

Smed-dynA-1 is a planarian nervous system specific dynamin 1 homolog required for normal locomotion.

Talbot JA, Currie KW, Pearson BJ, Collins EM.
Biol Open. 2014 Jun 20;3(7):627-34.

2013

Transcription factors lhx1/5-1 and pitx are required for the maintenance and regeneration of serotonergic neurons in planarians.
Currie KW, Pearson BJ.
Development. 2013 Sep;140(17):3577-88.

The Retinoblastoma pathway regulates stem cell proliferation in freshwater planarians.

Zhu SJ, Pearson BJ.
Dev Biol. 2013 Jan 15;373(2):442-52.

Genome-wide analysis of the bHLH gene family in planarians identifies factors required for adult neurogenesis and neuronal regeneration.
Cowles MW, Brown DD, Nisperos SV, Stanley BN, Pearson BJ, Zayas RM.
Development. 2013 Dec;140(23):4691-702.

2012

A comparative transcriptomic analysis reveals conserved features of stem cell pluripotency in planarians and mammals.
Labbé RM, Irimia M, Currie KW, Lin A, Zhu SJ, Brown DD, Ross EJ, Voisin V, Bader GD, Blencowe BJ, Pearson BJ.
Stem Cells. 2012 Aug;30(8):1734-45.

Proteomic profiling of the planarian Schmidtea mediterranea and its mucous reveals similarities with human secretions and those predicted for parasitic flatworms.
Bocchinfuso DG, Taylor P, Ross E, Ignatchenko A, Ignatchenko V, Kislinger T, Pearson BJ, Moran MF.
Mol Cell Proteomics. 2012 Sep;11(9):681-91.

TORC1 is required to balance cell proliferation and cell death in planarians.
Tu KC, Pearson BJ, Sánchez Alvarado A.
Dev Biol. 2012 May 15;365(2):458-69.

2010

A planarian p53 homolog regulates proliferation and self-renewal in adult stem cell lineages.
Pearson BJ, Sánchez Alvarado A.
Development. 2010 Jan;137(2):213-21.

2009

Formaldehyde-based whole-mount in situ hybridization method for planarians.
Pearson BJ, Eisenhoffer GT, Gurley KA, Rink JC, Miller DE, Sánchez Alvarado A.
Dev Dyn. 2009 Feb;238(2):443-50.

2008

Planarian PTEN homologs regulate stem cells and regeneration through TOR signaling.
Oviedo NJ, Pearson BJ, Levin M, Sánchez Alvarado A.
Dis Model Mech. 2008 Sep-Oct;1(2-3):131-43.

Regeneration, stem cells, and the evolution of tumor suppression.
Pearson BJ, Sánchez Alvarado A.
Cold Spring Harbor symposia on quantitative biology. 2008; 73:565-72.

2006

Hhip regulates zebrafish muscle development by both sequestering Hedgehog and modulating localization of Smoothened.
Ochi H, Pearson BJ, Chuang PT, Hammerschmidt M, Westerfield M.
Dev Biol. 2006 Sep 1;297(1):127-40.

2005

Regulation of temporal identity transitions in Drosophila neuroblasts.
Grosskortenhaus R, Pearson BJ, Marusich A, Doe CQ.
Dev Cell. 2005 Feb;8(2):193-202.

2004

Specification of temporal identity in the developing nervous system.
Pearson BJ, Doe CQ.
Annu Rev Cell Dev Biol. 2004;20:619-47. Review.

Molecular characterization, functional expression and tissue distribution of a second NCKX Na+/Ca2+ -K+ exchanger from Drosophila.

Winkfein RJ, Pearson B, Ward R, Szerencsei RT, Colley NJ, Schnetkamp PP.
Cell Calcium. 2004 Aug;36(2):147-55.

2003

Regulation of neuroblast competence in Drosophila.

Pearson BJ, Doe CQ.
Nature. 2003 Oct 9;425(6958):624-8.

2002

Potassium-dependent sodium-calcium exchange through the eye of the fly.

Webel R, Haug-Collet K, Pearson B, Szerencsei RT, Winkfein RJ, Schnetkamp PP, Colley NJ.
Annals of the New York Academy of Sciences. 2002; 976:300-14.

2001

Drosophila neuroblasts sequentially express transcription factors which specify the temporal identity of their neuronal progeny.

Isshiki T, Pearson B, Holbrook S, Doe CQ.
Cell. 2001; 106(4):511-21.

The homeobox gene lim-6 is required for distinct chemosensory representations in C. elegans.

Pierce-Shimomura JT, Faumont S, Gaston MR, Pearson BJ, Lockery SR.
Nature. 2001; 410(6829):694-8.

1999

Cloning and characterization of a potassium-dependent sodium/calcium exchanger in Drosophila.

Haug-Collet K, Pearson B, Webel R, Szerencsei RT, Winkfein RJ, Schnetkamp PP, Colley NJ.
The Journal of Cell Biology. 1999; 147(3):659-70.

Recruitment of a hedgehog regulatory circuit in butterfly eyespot evolution

Keys DN, Lewis DL, Selegue JE, Pearson BJ, Goodrich LV, Johnson RL, Gates J, Scott MP, Carroll SB
Science. 1999 Jan 22;283(5401):532-4

Big Bang